منابع مشابه
Biochemical nature of Russell Bodies.
Professional secretory cells produce and release abundant proteins. Particularly in case of mutations and/or insufficient chaperoning, these can aggregate and become toxic within or amongst cells. Immunoglobulins (Ig) are no exception. In the extracellular space, certain Ig-L chains form fibrils causing systemic amyloidosis. On the other hand, Ig variants lacking the first constant domain conde...
متن کاملMott cell (Russell bodies) Barrett's oesophagitis.
The first case of Barrett's oesophagus with chronic inflammation having predominantly (> 50%) Mott cells, i.e. plasma cells with stored immunoglobulins, known as Russell bodies, is reported. Biopsies from two oesophagoscopies revealed similar changes, suggesting that the predominance of Mott cells is not a fortuitous event but a more long-lasting microscopic process. Periodic acid-Schiff (PAS) ...
متن کاملMultiple myeloma with numerous intranuclear Russell bodies.
Correspondence: A. Martín-Noya, M.D., Servicio de Hematología, Hospital Universitario Virgen del Rocío, Avda. Manuel Siurot s/n1, 41013 Seville, Spain. Phone: international +34-95-4248122 – Fax: international +34-954248124 – E-mail: [email protected] A71-year-old woman was admitted to hospital because of repeated episodes of epistaxis and an eight month history of fatigue and weight loss. On ph...
متن کاملCirculating plasma cells with Russell bodies in osteosclerotic myeloma.
A 58-year-old white female had severe bone pain for 1 week. Increased levels of free l light chain (2423 mg/L) were present in the serum with decreased levels of all immunoglobulins. The complete blood count and differential were within normal limits. The peripheral blood smear had increased rouleaux formation and atypical plasma cells containing numerous cytoplasmic Russell bodies (panel A). T...
متن کاملRussell bodies in a skin biopsy: a case report
INTRODUCTION The presence of eosinophilic bodies in a skin biopsy can be found in a variety of situations and this may present a challenge to the pathologist. The differential diagnosis of these eosinophilic structures include microorganisms such as histoplasmosis or cryptococcosis, fungi, Michaelis-Gutmann bodies, deposits of amyloid or immunoglobulins, colloid bodies or elastic bodies. CASE...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2009
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.21395